Aim To evaluate the therapeutic effect of Dushen decoction on patients with acute myocardial infarction (AMI) and its influence on cardiac function and myocardial reperfusion. Methods 74 AMI patients in convalescent stage after myocardial infarction were randomly divided into two groups. The control group (37 cases) was treated with aspirin enteric coated tablets, atorvastatin and low molecular weight heparin calcium, while the observation group (37 cases) was treated with Dushen decoction on the basis of conventional therapy. The changes of serum biochemical indexes of AMI, cardiac function, hemodynamic indexes and quality of life were observed. Results After treatment, the levels of cardiac troponin I (cTnI), creatine kinase isoenzyme (CK-MB) and myoglobin in the observation group were lower than those in the control group (P＜0.05). Compared with the control group, left ventricular end diastolic volume(LVEDV) and left ventricular end systolic volume(LVESV) were significantly lower in the observation group after treatment (P＜0.05), left ventricular ejection fraction(LVEF), systolic blood pressure(SBP), diastolic blood pressure(DBP) and cardiac output, physical function, emotional cognition, health status, social function and total score of QLQC30 were significantly higher in the observation group after treatment (P＜0.05). Logistic regression analysis showed that serum biochemical indexes of AMI, heart function, blood pressure and hemodynamic indexes were independent risk factors for myocardial injury in patients with myocardial infarction. Conclusion The patients with AMI in convalescent stage after myocardial infarction were treated with traditional Chinese medicine Dushen decoction, which can improve myocardial reperfusion, cardiac function and hemodynamic indexes, and create better conditions for patients' quality of life after treatment.