Aim To explore the regularity and difference of cardiovascular aging of Han nationality in Urumqi and Yili. Methods A total of 474 Han residents with self-rated health were selected from Urumqi and Yili, including 314 in Urumqi and 160 in Yili. The rules and differences of cardiovascular aging of Han nationality in Urumqi and Yili were compared by means of on-the-spot investigation, laboratory detection and cardiac color ultrasound examination. Results Among the cardiovascular aging related indexes of Han nationality in Urumqi and Yili, systolic blood pressure (SBP), pulse pressure (PP), pulse pressure index (PPI), blood urea nitrogen (BUN), serum creatinine (SCr), cystatin C (CysC), ascending aorta diameter (AAD), left atrial longitudinal diameter (LAD), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), right atrial diameter (RAD), right ventricular diameter (RVD) and pulmonary arterial diameter (PAD) increased with age. However, the indexes of plasma albumin (ALB) and left ventricular ejection fraction (LVEF) decreased with age, the indexes that can be used as markers of cardiovascular aging were SBP, PP, BUN, CysC, ALB, LAD, LVEDD, LVESD, RVD, LVEF. Comparison between different regions in the same age group:the progression of cardiovascular aging increased with age in the 30～44 years old group and the 45～59 years old group of the Han nationality in the two regions, and Urumqi progressed faster than Yili; The cardiovascular aging process of Han nationality was faster in 60～74 years old group than that of the former two age groups, and the progress in Yili was faster than that in Urumqi. In the group of ≥75 years old, the progression of cardiovascular aging in Han nationality was faster in Urumqi than in Yili. Conclusion With the increase of age, the cardiovascular aging process of healthy Han residents is not constant in Urumqi and Yili, among the four age groups, the cardiovascular aging process of Han nationality is the fastest in 60～74 years old group, and 60 years old may be the threshold inflection point of accelerated cardiovascular aging.