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王亚南,黄引芳,杨露,邵琦,张倩,杜冬梅,黄高忠,郭倩.阻塞性睡眠呼吸暂停低通气综合征患者颈动脉内膜中膜厚度及其与外周血25羟维生素D水平的关系[J].中国动脉硬化杂志,2020,(10):890~894
阻塞性睡眠呼吸暂停低通气综合征患者颈动脉内膜中膜厚度及其与外周血25羟维生素D水平的关系
Carotid intima-media thickness and its correlation with 25(OH)D in obstructive sleep apnea hypopnea syndrome patients
投稿时间:2019-10-20  修订日期:2020-01-29
DOI:
中文关键词:  睡眠呼吸暂停低通气综合征  动脉粥样硬化  颈动脉内膜中膜厚度  25羟维生素D
英文关键词:obstructive sleep apnea hypopnea syndrome  atherosclerosis  carotid intima-media thickness  25(OH)D
基金项目:国家科技部基金项目(2018YFC1313700)
作者单位E-mail
王亚南 上海交通大学附属第六人民医院特需医疗科,上海市 200030
上海市浦东新区北蔡社区卫生服务中心,上海市 200120 
e-mail为17301810058@163.com,e-mail为huanggaozhong@126.com 
黄引芳 上海交通大学附属第六人民医院特需医疗科,上海市 200030  
杨露 上海交通大学附属第六人民医院特需医疗科,上海市 200030  
邵琦 上海交通大学附属第六人民医院特需医疗科,上海市 200030  
张倩 上海交通大学附属第六人民医院特需医疗科,上海市 200030  
杜冬梅 上海交通大学附属第六人民医院特需医疗科,上海市 200030  
黄高忠 上海交通大学附属第六人民医院特需医疗科,上海市 200030 e-mail为17301810058@163.com,e-mail为huanggaozhong@126.com 
郭倩 同济大学附属东方医院呼吸与危重症医学科,上海市 200120  
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中文摘要:
      目的 了解睡眠呼吸暂停低通气综合征(OSAHS)患者颈动脉内膜中膜厚度(CIMT)的变化,探索OSAHS患者CIMT与25羟维生素D(25(OH)D)水平的相关性。方法 使用便携式睡眠监测仪(PM)对体检人群进行监测;根据睡眠呼吸暂停低通气指数(AHI)将其分为对照组、轻度OSAHS组、中度OSAHS组和重度OSAHS组。比较4组CIMT和25(OH)D水平,分析CIMT与25(OH)D的相关性。结果 重度OSAHS组CIMT[(0.88±0.15) mm]较对照组及轻度OSAHS组升高[分别为[(0.75±0.14) mm和(0.76±0.14) mm,均P<0.05],差异有统计学意义。中度及重度OSAHS组25(OH)D水平[分别为(19.06±6.04) μg/L和(17.67±4.73) μg/L]均低于对照组[(22.78±7.40) μg/L,均P<0.05],差异有统计学意义。多重线性回归分析校正各混杂因素的影响后,OSAHS患者CIMT与AHI呈正相关(P=0.006),与25(OH)D呈负相关(P=0.024)。结论 OSAHS患者CIMT增厚,且随着OSAHS严重程度的增加,CIMT增加。25(OH)D缺乏可能是OSAHS患者发生颈动脉内膜增厚的危险因素。
英文摘要:
      Aim To investigate the changes of carotid intima media thickness (CIMT) in patients with sleep apnea hypopnea syndrome (OSAHS), and to explore the correlation between CIMT and 25(OH)D levels in OSAHS patients.Methods The portable sleep monitor (PM) was used to monitor the sleep condition of the people reference for the health examination. According to sleep apnea hypopnea index (AHI), they were divided into control group, mild OSAHS group, moderate OSAHS group and severe OSAHS group. CIMT and the levels of 25(OH)D in the four groups were compared to analyze the correlation between CIMT and 25(OH)D. Results CIMT in severe OSAHS group was higher than that in control group and mild OSAHS group ((0.88±0.15) mm vs (0.75±0.14) mm and (0.76±0.14) mm, all P<0.05), the difference was statistically significant. The level of 25(OH)D in the moderate and severe OSAHS group was lower than that in the control group ((19.06±6.04) μg/L and (17.67±4.73) μg/L vs (22.78±7.40) μg/L, all P<0.05), the difference was statistically significant. After adjusting the influences of various hybrid factors, multiple linear regression analysis demonstrated that CIMT in OSAHS patients was positively correlated with AHI (P=0.006) and negatively correlated with 25(OH)D (P=0.024). Conclusion CIMT in OSAHS patients increases with the increase of severity. 25(OH)D deficiency may be a risk factor for carotid intimal thickening in OSAHS patients.
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