• 高级搜索
  • 进入期刊界搜索引擎>>
杨秀红,王玉强,杜正任,魏延津.高脂血症冠状动脉内皮损伤相关的微小RNA研究进展[J].中国动脉硬化杂志,2020,(8):721~727
高脂血症冠状动脉内皮损伤相关的微小RNA研究进展
Research progress of miRNA related to hyperlipidemia induced coronary arterial endothelial injury
投稿时间:2019-12-31  修订日期:2020-02-24
DOI:
中文关键词:  微小RNA  冠状动脉粥样硬化  高脂血症  ox-LDL  内皮损伤
英文关键词:microRNA  coronary atherosclerosis  hyperlipidemia  ox-LDL  endothelial injury
基金项目:山东省自然科学基金(ZR2018BH032)
作者单位E-mail
杨秀红 潍坊医学院,山东省潍坊市 261053 e-mail为yangxiuhong2012@yeah.net,e-mail为weiyanjin1968@126.com 
王玉强 临沂市人民医院心血管内科,山东省临沂市 276000  
杜正任 潍坊医学院,山东省潍坊市 261053  
魏延津 临沂市人民医院心血管内科,山东省临沂市 276000 e-mail为yangxiuhong2012@yeah.net,e-mail为weiyanjin1968@126.com 
摘要点击次数: 279
全文下载次数: 138
中文摘要:
      目前认为冠状动脉血管内皮的损伤是冠状动脉粥样硬化形成的关键始动因素,氧化型低密度脂蛋白(ox-LDL)对内皮细胞的损伤机制一直都是研究的热点。新技术方法的开展使得微小RNA(miRNA)在ox-LDL所导致内皮细胞损伤过程中的作用被逐渐发现。本文简述了在高脂血症条件下涉及冠状动脉内皮细胞炎症、自噬、凋亡及功能障碍等内皮损伤作用的miRNAs。这些miRNA或许可为冠状动脉粥样硬化的预测、诊断甚至治疗提供新方向。
英文摘要:
      Coronary artery endothelial injury is the initiating and the most critical factor of atherogenesis. For a long time, researchers have focused on the mechanism of endothelial injury induced by oxidized low density lipoprotein(ox-LDL). With the development of new technologies and methods, the role of micro-RNA (miRNA) in the process of endothelial cell injury induced by ox-LDL has been gradually discovered. This review briefly describes the miRNAs involved in endothelial injury such as endothelial inflammation, autophagy, apoptosis and dysfunction under the condition of hyperlipidemia. Summarizing these miRNAs may permit new ideas for the prediction, diagnosis and even treatment of coronary atherosclerosis.
查看全文  查看/发表评论  下载PDF阅读器
关闭




您是本站第 9994317位访问者
版权所有:中国动脉硬化杂志  湘ICP备11008367号
主管单位:中国科学技术协会  主办单位:中国病理生理学会、南华大学
电话:0734-8160765  传真:0734-8160523  E-mail:dmzzbjb@163.net  网址:www.dmzzbjb.net
function PdfOpen(url){ var win="toolbar=no,location=no,directories=no,status=yes,menubar=yes,scrollbars=yes,resizable=yes"; window.open(url,"",win); } function openWin(url,w,h){ var win="toolbar=no,location=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=no,width=" + w + ",height=" + h; controlWindow=window.open(url,"",win);}&et=FC9DA7BF2F842A3BAE24B54F70914FE6F76164CC55DC859C4D4511A2007F1EBFE35015FAFA5C3CE4B9D61FB63D8750339721E287C6F623697B6D25CAC1FC1CCF8FE777BBF84BFDF39735599C5067BE64AA9E55CA01B293993893C94AEBFE98A2C6EC5639B7B78C42&pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=AD36F34DDC3BA7B0&jid=&yid=0D1D160AB8016934&aid=&vid=&iid=5D311CA918CA9A03&sid=569BDAA4FEA0F7F9&eid=0EE24608F5763811&fileno=20200815&flag=1&is_more=0">var my_pcid="A9DB1C13C87CE289EA38239A9433C9DC";var my_cid="AD36F34DDC3BA7B0";var my_jid="";var my_yid="0D1D160AB8016934";var my_aid="";