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党晶艺,郝启萌,蒋娜,陈江红.血清脂蛋白(a)、β2微球蛋白和肿瘤坏死因子α水平与急性冠状动脉综合征患者冠状动脉病变程度的关系[J].中国动脉硬化杂志,2020,(8):702~706
血清脂蛋白(a)、β2微球蛋白和肿瘤坏死因子α水平与急性冠状动脉综合征患者冠状动脉病变程度的关系
Relationship between serum lipoprotein(a), β2-microglobulin and tumor necrosis factor-α levels and degree of coronary artery lesion in patients with acute coronary syndrome
投稿时间:2019-06-13  修订日期:2019-08-26
DOI:
中文关键词:  脂蛋白(a)  β2微球蛋白  肿瘤坏死因子α  急性冠状动脉综合征  冠状动脉病变程度  动脉粥样硬化
英文关键词:lipoprotein(a)  β2-microglobulin  tumor necrosis factor-α  acute coronary syndrome  degree of coronary artery lesion  atherosclerosis
基金项目:空军军医大学唐都医院骨干人才资助基金(2017-22)
作者单位E-mail
党晶艺 空军军医大学唐都医院心内科,陕西省西安市 710000 e-mail为maozoua@163.com,e-mail为1578612717@qq.com 
郝启萌 空军军医大学唐都医院心内科,陕西省西安市 710000  
蒋娜 甘肃省人民医院心内科,甘肃省兰州市 730000  
陈江红 空军军医大学唐都医院心内科,陕西省西安市 710000 e-mail为maozoua@163.com,e-mail为1578612717@qq.com 
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中文摘要:
      目的 观察血清脂蛋白(a)[Lp(a)]、β2微球蛋白(β2-MG)和肿瘤坏死因子α(TNF-α)水平与急性冠状动脉综合征(ACS)患者冠状动脉病变程度的关系,分析其临床意义。方法 收集2015年6月至2018年6月入院确诊为ACS患者87例,其中54例为不稳定型心绞痛(UA),33例为急性心肌梗死(AMI),另选取同期年龄、性别基本匹配的健康者32例作为对照组。检测所有受试者血清Lp(a)、β2-MG和TNF-α水平,分析其与冠状动脉病变程度的关系。结果 与对照组相比,ACS患者血清中Lp(a)、β2-MG和TNF-α水平均显著上升(P<0.05),且AMI组血清中Lp(a)、TNF-α水平均显著高于UA组(P<0.05)。随着冠状动脉病变支数和修正Gensini积分等级的增加,ACS患者血清中Lp(a)、β2-MG和TNF-α水平也随之上升(P<0.05)。Pearson相关分析显示,血清Lp(a)、β2-MG、TNF-α水平分别与ACS患者冠状动脉病变支数、修正Gensini积分等级呈正相关(P<0.05)。Logistic回归分析表明,除常规ACS影响因素外,血清Lp(a)、β2-MG、TNF-α水平是ACS的独立风险因素。结论 ACS患者血清Lp(a)、β2-MG和TNF-α水平与ACS患者冠状动脉病变程度呈正相关;随着ACS患者病情加剧,血清Lp(a)、β2-MG和TNF-α水平也随之上升。
英文摘要:
      Aim To observe the relationship between serum lipoprotein(a) [Lp(a)], β2-microglobulin (β2-MG) and tumor necrosis factor-α (TNF-α) levels and degree of coronary artery lesion in patients with acute coronary syndrome (ACS), and to analyze their clinical significance. Methods A total of 87 patients diagnosed as ACS from June 2015 to June 2018 was collected, including 54 cases of unstable angina pectoris (UA) and 33 cases of acute myocardial infarction (AMI). Another 32 healthy person with basically matched age and gender in the same period were selected as control group. The levels of serum Lp(a), β2-MG and TNF-α were detected in all subjects, and the relationship between their levels and degree of coronary artery lesion was analyzed. Results Compared with control group, serum levels of Lp(a), β2-MG and TNF-α in ACS patients were increased significantly (P<0.05), and serum levels of Lp(a) and TNF-α in AMI group were significantly higher than those in UA group (P<0.05). With the increase of coronary artery lesion number and modified Gensini score grading, the serum levels of Lp(a), β2-MG and TNF-α in ACS patients were also increased (P<0.05). Pearson correlation analysis showed that serum Lp(a), β2-MG and TNF-α levels were positively correlated with the number of coronary lesions and the modified Gensini score grading in ACS patients, respectively (P<0.05). Logistic regression analysis showed that serum Lp(a), β2-MG and TNF-α levels were independent risk factors for ACS, in addition to the conventional influencing factors of ACS. Conclusions Serum levels of Lp(a), β2-MG and TNF-α in ACS patients are positively correlated with the degree of coronary artery lesions. With the disease aggravation of ACS patients, serum levels of Lp(a), β2-MG and TNF-α also rise.
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