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李宁,朱国斌.冠心病患者T细胞免疫球蛋白黏蛋白分子3与肿瘤坏死因子α、白细胞介素6变化的研究[J].中国动脉硬化杂志,2020,(8):692~696
冠心病患者T细胞免疫球蛋白黏蛋白分子3与肿瘤坏死因子α、白细胞介素6变化的研究
Study on the changes of T cell immunoglobulin and mucin-domain containing molecule family-3, tumor necrosis factor α and interleukin-6 in patients with coronary heart disease
投稿时间:2019-04-13  修订日期:2020-01-03
DOI:
中文关键词:  冠心病  T细胞免疫球蛋白黏蛋白分子3  肿瘤坏死因子α  白细胞介素6
英文关键词:coronary heart disease  T cell immunoglobulin and mucin-domain containing molecule family-3  tumor necrosis factor-α  interleukin-6
基金项目:
作者单位E-mail
李宁 山西医科大学第二医院心内科,山西省太原市 030000 e-mail为369400244@qq.com,e-mail为19834515760@139.com 
朱国斌 山西医科大学第二医院心内科,山西省太原市 030000 e-mail为369400244@qq.com,e-mail为19834515760@139.com 
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中文摘要:
      目的 探讨冠心病患者外周血CD14+单核细胞膜型T细胞免疫球蛋白黏蛋白分子3(flTim-3)的阳性率及外周血清中可溶性Tim-3(sTim-3)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)浓度的变化及临床意义。方法 以196例拟诊冠心病者为研究对象,所有入选者均行冠状动脉造影。根据冠状动脉造影结果和冠心病诊断标准,把入选患者分为非冠心病组(n=54)、稳定型心绞痛(SAP)组(n=87)、急性冠状动脉综合征(ACS)组(n=55)。记录一般资料。采用流式细胞仪测定外周血单核细胞flTim-3的阳性率,采用酶联免疫吸附法测定血清sTim-3、TNF-α、IL-6的浓度。结果 与非冠心病组比较,SAP组、ACS组患者flTim-3阳性率、TNF-α、IL-6浓度增高,且ACS组更高,差异有统计学意义(P<0.05);而sTim-3浓度降低,且ACS组更低,差异有统计学意义(P<0.05)。Pearson相关分析显示,flTim-3与TNF-α、IL-6呈正相关,sTim-3与TNF-α、IL-6呈负相关(P<0.01)。Logistic回归分析显示,flTim-3、sTim-3、TNF-α、IL-6与冠心病临床表型具有相关性(P<0.05)。结论 flTim-3、sTim-3可能通过调节单核/巨噬细胞炎症因子的表达而影响冠心病的临床表型,flTim-3、sTim-3对冠心病临床表型有预测价值。
英文摘要:
      Aim To investigate the changes of the positive rate of full-length membrane-enchored T cell immunoglobulin and mucin-domain containing molecule family-3 (flTim-3) on CD14+ monocyte in peripheral blood and the levels of serum soluble Tim-3 (sTim-3), tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) in patients with coronary heart disease (CHD) and their clinical significance. Methods 196 suspected CHD patients were selected as the study subjects, and all the selected patients underwent coronary angiography. According to the results of coronary angiography and CHD diagnostic criteria, the selected patients were divided into non-CHD group (n=54), stable angina pectoris (SAP) group (n=87) and acute coronary syndrome (ACS) group (n=55). General information was recorded. The positive rate of flTim-3 in peripheral blood monocytes was determined by flow cytometry. The concentrations of serum sTim-3, TNF-α and IL-6 were measured by enzyme-linked immunosorbent assay. Results Compared with non-CHD group, flTim-3 positive rate, TNF-α, IL-6 concentrations in SAP group and ACS group were higher, and ACS group was higher more, the difference was statistically significant (P<0.05); While sTim-3 concentration was lower, ACS group was lower more, the difference was statistically significant (P<0.05). Pearson correlation analysis showed that flTim-3 was positively correlated with TNF-α and IL-6, while sTim-3 was negatively correlated with TNF-α and IL-6 (P<0.01). Logistic regression analysis showed that flTim-3, sTim-3, TNF-α, IL-6 were correlated with the clinical phenotype of CHD (P<0.05). Conclusion FlTim-3 and sTim-3 affect the clinical phenotype of CHD by regulating the expression of monocyte/macrophage inflammatory factors. FlTim-3 and sTim-3 have predictive value for the clinical phenotype of CHD.
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