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柴三葆,辛思旭,袁宁,刘玉芳,孙健斌,张晓梅.瘦素与2型糖尿病患者合并下肢动脉粥样硬化的相关性[J].中国动脉硬化杂志,2020,(8):658~661
瘦素与2型糖尿病患者合并下肢动脉粥样硬化的相关性
Correlation between leptin and lower extremity atherosclerosis in patients with type 2 diabetes mellitus
投稿时间:2020-03-10  修订日期:2020-05-15
DOI:
中文关键词:  2型糖尿病  下肢动脉粥样硬化  瘦素
英文关键词:type 2 diabetes mellitus  lower extremity atherosclerosis  leptin
基金项目:国家自然科学基金青年基金项目(81700779);北京大学国际医院院内科研基金(YN2016QN05)
作者单位E-mail
柴三葆 北京大学国际医院内分泌科,北京市 102206 e-mail为chaisb@126.com,e-mail为z.x.mei@163.com 
辛思旭 北京大学国际医院内分泌科,北京市 102206  
袁宁 北京大学国际医院内分泌科,北京市 102206  
刘玉芳 北京大学国际医院内分泌科,北京市 102206  
孙健斌 北京大学国际医院内分泌科,北京市 102206  
张晓梅 北京大学国际医院内分泌科,北京市 102206 e-mail为chaisb@126.com,e-mail为z.x.mei@163.com 
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中文摘要:
      目的 探讨瘦素与2型糖尿病患者下肢动脉粥样硬化的相关性。方法 选取2016年9月至2017年1月就诊于北京大学国际医院内分泌科的男性2型糖尿病患者71例,均行下肢动脉超声检查,根据是否合并下肢动脉粥样硬化分成下肢动脉粥样硬化组(38例)和无下肢动脉粥样硬化组(33例)。比较两组患者一般资料、生化指标和瘦素水平,采用多因素Logistic回归分析2型糖尿病患者下肢动脉粥样硬化的危险因素。结果 两组患者年龄、糖尿病病程、体质指数、血压、血脂差异均无统计学意义(P>0.05)。下肢动脉粥样硬化组较无下肢动脉粥样硬化组 空腹血糖[7.97(6.37,9.37) mmol/L比6.97(6.27,8.04) mmol/L]、糖化血红蛋白[(8.15%±1.79%)比(7.31%±1.22%)]和瘦素水平[(227.60±58.08) ng/L比(176.60±43.94) ng/L]均显著升高(P<0.05)。多因素Logistic回归分析提示瘦素(OR=1.016,95%CI 1.002~1.030,P=0.024)及糖化血红蛋白(OR=1.745,95%CI 1.060~2.874,P=0.029)是2型糖尿病患者下肢动脉粥样硬化的危险因素(P<0.05)。结论 瘦素与2型糖尿病患者合并下肢动脉粥样硬化的发生有相关性。
英文摘要:
      Aim To investigate the relationship between leptin and lower extremity atherosclerosis in patients with type 2 diabetes mellitus(T2DM). Methods Totally 71 male patients with T2DM were divided into 38 patients with lower extremity atherosclerosis and 33 patients without lower extremity atherosclerosis according to the results of lower limb artery color ultrasound. General information, biochemical indicators and serum leptin levels of the two groups were compared. Multivariate Logistic regression was used to analyze the risk factors of lower extremity atherosclerosis in T2DM. Results Serum fasting blood glucose (7.97(6.7,9.37) mmol/L vs 6.97(6.7,8.04) mmol/L), glycated haemoglobin A1c (HbA1c)((8.15%±1.79%) vs (7.31%±1.22%)) and leptin levels ((227.60±58.08) ng/L vs (176.60±43.94) ng/L) were significantly higher in the group with lower extremity atherosclerosis than those in the group without lower extremity atherosclerosis (P<0.05). High serum leptin level(OR=1.6,5%CI 1.002~1.030, P=0.024) and HbA1c(OR=1.5,5%CI 1.060~2.874, P=0.029) were the risk factors of lower extremity atherosclerosis in patients with T2DM. Conclusion The serum level of leptin is the risk factor of lower extremity atherosclerosis in patients with T2DM.
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