Aim Tissue Doppler imaging (TDI) and two-dimensional speckle tracking imaging (2D-STI) were used to evaluate the changes of left atrial pressure and function and their relationship with left ventricular function in patients with coronary heart disease (CHD) before and after percutaneous coronary intervention (PCI), so as to provide more effective information for clinical treatment of CHD. Methods Maximal left atrial volume (LAV_max), minimal left atrial volume (LAV_min), pre-atrial contraction left atrial volume (LAV_pre), left atrial passive emptying fraction (LAPEF), left atrial active emptying fraction (LAAEF), left ventricular ejection fraction (LVEF), early velocity of mitral valve (E), atrial contractile velocity of mitral valve (A) were measured and calculated by echocardiography before PCI, 1 week after PCI and 3 months after PCI in 30 CHD patients. Early diastole velocity of mitral valve annulus (e’), left atrial mean pressure (mLAP), E/A and E/e’ were measured and calculated by TDI. Left ventricular systolic global longitudinal strain (GLS), mean systolic peak strain rate (mSRs), mean early diastolic peak strain rate (mSRe), mean late diastolic peak strain rate (mSRa) were measured and calculated by 2D-STI. Another 30 cases with coronary artery stenosis rate less than 30% measured by coronary angiography were selected as the control group. Results Compared with the control group, LVEF, LAPEF, E, E/A, e’, mSRs, mSRe and GLS decreased, A, E/e’, mLAP, LAV_min, LAV_max, LAV_pre, LAAEF and mSRa increased at different time in the CHD group (P＜0.05). In the CHD group, there were no significant difference in all the indexes between 1 week after PCI and before PCI (P＞0.05); Compared with before PCI and 1 week after PCI, E, e’, E/A, mSRs, mSRe, GLS, LVEF and LAPEF increased, while A, E/e’, mLAP, LAV_min, LAV_max, LAV_pre, LAAEF and mSRa decreased at 3 months after PCI (P＜0.05). At 3 months after PCI in the CHD group, mLAP was positively correlated with GLS, mSRe, LAV_min, LAV_max and LAV_pre (r＝0.8,0.1,0.1,0.8,0.857, P＜0.01), and negatively correlated with LVEF, E/A, mSRa, mSRs and LAPEF (r＝－0.800, －0.884, －0.898, －0.829, －0.427, P＜0.05). Conclusions The function of left atrium and left ventricle in CHD patients is improved significantly in 3 months after PCI compared with that in 1 week after PCI and before PCI. The changes of left atrial pressure and function can comprehensively reflect the changes of left atrial and left ventricular function in CHD patients after PCI, which are closely related to each other.