The outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been pandemic and become a major global public health emergency. The typical clinical manifestations of coronavirus disease 2019 (COVID-19) are mainly respiratory symptoms, but the induced damage to cardiovascular system has been reported, which cannot be ignored. What cardiovascular damage can SARS-CoV-2 infection cause? What are the involved mechanisms? How to take measures for better prevention and treatment against cardiovascular damage caused by this novel virus infection? How to regulate the use of cardiovascular drugs in patients with cardiovascular disease combined with COVID-19? These unknowns need to be explored urgently. Starting from this issue, a column titled “SARS-CoV-2 infection and cardiovascular injury” is delivered for two consecutive issues. Experts in relevant fields are invited to expound on these questions and report their clinical investigations. The purpose of this column is to deepen the understanding of COVID-19 and its cardiovascular injury and improve the prevention and treatment.