Aim To investigate the association of CYP2C19 gene polymorphism with coronary heart disease (CHD) and its types in Shanxi Han population. Methods 693 unrelated Han patients from Shanxi province were randomly collected from January 2017 to June 2018. According to the results of coronary angiography, clinical manifestations, electrocardiogram and myocardial injury markers, 478 cases were classified as CHD group (including 50 cases of stable angina pectoris, 157 cases of unstable angina pectoris, 271 cases of acute myocardial infarction), and 215 cases without coronary artery disease were classified as control group. Then, CYP2C19 genotypes were detected and the difference of genotype and allele distribution were observed and compared between the two groups. Results The frequency of CYP2C19*1/*2 genotype distribution in CHD group was higher than that in control group (P=0.002). The frequency of CYP2C19*2 allele distribution was higher in CHD group than that in control group (P=0.011). There was no significant difference in the frequency of genotype and allele distribution between the control group and three different types of CHD (P>0.05). Moreover, the Logistic regression analysis showed that the CYP2C19*1/*2 genotype was associated with the increased risk of CHD (OR=1.8,5%CI 1.252～2.698), when factors such as sex, age, diabetes, smoking history, hypertension were excluded. Conclusion CYP2C19 gene polymorphism is a risk factor for CHD in Shanxi Han population, but it is not associated with different types of CHD.