小而密低密度脂蛋白与冠心病的研究进展
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(中国医科大学附属盛京医院第三心血管内科,辽宁省沈阳市 110004)

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安宁,硕士研究生,研究方向为冠心病、心力衰竭、心律失常等疾病诊治,E-mail为785929099@qq.com。通信作者邹德玲,博士,教授,主任医师,硕士研究生导师,研究方向为心律失常及电生理治疗,以及冠心病、心力衰竭、心肌病等疾病诊治,E-mail为zoudl@sj-hospital.org。

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Research progress of small dense low density lipoprotein and coronary heart disease
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Department of the Third Cardiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China)

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    摘要:

    目前公认的以低密度脂蛋白(LDL)作为冠心病(CHD)防治的主要干预目标,然而许多LDL在正常范围的患者仍然会发生冠状动脉粥样硬化,因此,国内外研究学者进一步研究LDL亚组发现,小而密低密度脂蛋白(sd-LDL)具有更强的致动脉粥样硬化作用,而且较LDL作为CHD的独立危险因素更敏感。既往因检测方法的局限,sd-LDL检测未能大规模投入临床,近年来均相酶法的出现使其作为临床常规检验成为可能。sd-LDL作为CHD的危险因素与其发生发展密切相关,未来将进行更多的大型干预研究以确定sd-LDL的适当目标水平,更加精准有效的进行心血管风险评估及管理治疗。本文就sd-LDL的研究进展及其与CHD的关系予以综述。

    Abstract:

    Currently, low density lipoprotein(LDL) is the main intervention target for coronary heart disease(CHD) prevention and treatment. However, many patients with LDL in the normal range will still develop coronary atherosclerosis. Therefore, domestic and foreign researchers further studied the LDL subgroup and found that small dense low density lipoprotein(sd-LDL) has a stronger atherogenic effect than LDL. sd-LDL, as an independent risk factor of CHD, is more sensitive than LDL. In the past, due to the limitations of detection methods, the detection of sd-LDL has not been widely applied to clinical practice. In recent years, the presence of homogeneous enzyme makes it possible to be used as a clinical routine test. sd-LDL, as a risk factor of CHD, is closely related to its occurrence and development. In the future, more large intervention studies will be conducted to determine the appropriate target level of sd-LDL, and more accurate and effective cardiovascular risk assessment and management treatment will be conducted. This paper reviews the advances in sd-LDL and its relationship with CHD.

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安宁,邹德玲.小而密低密度脂蛋白与冠心病的研究进展[J].中国动脉硬化杂志,2019,27(7):639~644.

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  • 收稿日期:2018-11-13
  • 最后修改日期:2019-01-07
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  • 在线发布日期: 2019-06-04