Aim To assess the degree of improvement in the quality of life of coronary heart disease patients with chronic total occlusion(CTO) and decreased left ventricular ejection fraction(LVEF) one month after percutaneous coronary intervention(PCI) therapy. Methods 111 CTO coronary heart disease patients who received PCI successfully were included prospectively and continuously in this study. All these patients were divided into two groups, according to their results of preoperative LVEF. In one group(n=67) the LVEF of patients was normal(≥50%) while patients in another group(n=44) had a decreased LVEF(<50%). Questionnaires were conducted in these patients with SF-12 Health Survey and Seattle Angina Questionnaire(SAQ)48 hours before PCI, and it recorded the clinical data(age, gender, BMI, blood pressure, heart rate, LVEF, education, hospitalization days, medical history, PCI status and medicine, etc.). One month after PCI, SF-12 Health Survey and SAQ were conducted in these patients and the degree of improvement in quality of life was evaluated. Results All 111 CTO patients received successful PCI. Patients in group B were older and had a faster heart rate, longer hospital stays and a higher percentage of diabetes history(P<0.05).The occurrence of major adverse cardiac events one month after PCI in two groups are similar(P>0.05). NYHA cardiac functional class was significantly improved in both groups(P<0.01). The SF-12 Health Survey and SAQ scores of patients in group B were significantly higher one month later than those before the PCI(P<0.05), and the SF-12 Health Survey and SAQ scores of patients in group A also increased significantly in all aspects except the dimension of treatment satisfaction of SAQ(P<0.05). In addition, the SF-12 health survey and SAQ scores in group B were close to those in group A(P>0.05). Conclusion Successful PCI can significantly improve the short-term quality of life of CTO coronary heart disease patients with decreased LVEF, and the degree of improvement is close to that of patients with normal LVEF.