• 高级搜索
  • 进入期刊界搜索引擎>>
刘凤,易华,彭定琼,段俊婷,刘丽.2型糖尿病患者血浆Apelin-12水平与血糖的关系[J].中国动脉硬化杂志,2019,(3):247~250
2型糖尿病患者血浆Apelin-12水平与血糖的关系
The relationship between plasma apelin-12 and blood glucose in type 2 diabetes mellitus patients
投稿时间:2018-10-28  修订日期:2018-12-23
DOI:
中文关键词:  Apelin-12  2型糖尿病  血糖
英文关键词:apelin-12  type 2 diabetes mellitus  blood glucose
基金项目:
作者单位E-mail
刘凤 民航总医院内分泌科,北京市 100123 e-mail为liufeng0505@126.com,e-mail为dingpq@yeah.net 
易华 中国南方航空股份有限公司北京分公司后勤保障部,北京市101318  
彭定琼 民航总医院内分泌科,北京市 100123 e-mail为liufeng0505@126.com,e-mail为dingpq@yeah.net 
段俊婷 民航总医院内分泌科,北京市 100123  
刘丽 民航总医院内分泌科,北京市 100123  
摘要点击次数: 95
全文下载次数: 49
中文摘要:
      目的 探讨2型糖尿病患者血浆脂肪细胞因子Apelin-12水平变化及其与血糖的关系。方法 选取2012年1月至2015年6月在民航总医院内分泌科住院的41例2型糖尿病患者作为研究对象,并招募44例健康对照者作为对照组。根据有无合并冠心病、脑血管病及高血压病将2型糖尿病患者再分为2型糖尿病合并心脑血管疾病组(21例)和单纯糖尿病组(20例)。酶联免疫吸附法测定Apelin-12的水平,测定其糖化血红蛋白、总胆固醇、甘油三酯、低密度脂蛋白以及空腹和餐后2 h血糖、C肽的水平,并对以上指标进行相关性分析。结果 与对照组相比,2型糖尿病患者血浆Apelin-12水平显著降低(t=2.70,P=0.01);2型糖尿病合并心脑血管疾病组血浆Apelin-12的水平与单纯糖尿病组差异无统计学意义(t=-0.44,P=0.67)。多元逐步回归分析显示,在2型糖尿病患者中,空腹血糖与Apelin-12相关(B=-0.12,β=-0.42,t=-2.03,P=0.04)。结论 2型糖尿病患者血浆Apelin-12水平显著降低且与空腹血糖呈负相关。
英文摘要:
      Aim To investigate the plasma apelin-12 level in the subjects with type 2 diabetes mellitus(T2DM)and its relationship with blood glucose. Methods 41 T2DM patients who were hospitalized in the department of endocrinology of civil aviation general hospital were selected from January 2012 to June 2015, and 44 healthy subjects were enrolled as control group. The patients with T2DM were divided into two groups including one group (21 persons) complicated with hypertension, cardiovascular and cerebrovascular disease and another group (20 persons) without complications for subgroup analysis. The level of apelin-12 was measured by enzyme linked immunosorbent assay. Glycosylated hemoglobin (HbA1c), cholesterol, triglyceride, low density lipoprotein, fasting blood glucose, 2-hour postprandial glucose (2hPG) and C peptide were determined in T2DM group and control group. The correlation between apelin-12 and clinical indicators was analyzed. Results (1) The content of apelin-12 was significantly lower in the T2DM group than in control group(t=2.70, P=0.01). (2)Subgroup analysis showed that there was no significant difference in plasma apelin-12 level between T2DM with cardiovascular and cerebrovascular diseases and T2DM without complications (t=-0.44, P=0.67). (3) With stepwise multiple regression analysis, taking apelin-12 as dependent variable, and age, body mass index, blood pressure, total cholesterol, triglyceride, low density lipoprotein, high density lipoprotein, HbA1c, fasting blood glucose, 2-hour postprandial blood glucose, fasting C-peptide and 2-hour postprandial C-peptide were independent variables, fasting blood glucose was associated with apelin-12 in T2DM patients(B=-0.12, β=-0.42, t=-2.03, P=0.04).Conclusion Plasma apelin-12 levels were significantly lower in patients with T2DM and were negatively correlated with fasting blood glucose.
查看全文  查看/发表评论  下载PDF阅读器
关闭




您是本站第 7549677位访问者
版权所有:中国动脉硬化杂志  湘ICP备11008367号
主管单位:中国科学技术协会  主办单位:中国病理生理学会、南华大学
电话:0734-8160765  传真:0734-8160523  E-mail:dmzzbjb@163.net  网址:www.dmzzbjb.net
function PdfOpen(url){ var win="toolbar=no,location=no,directories=no,status=yes,menubar=yes,scrollbars=yes,resizable=yes"; window.open(url,"",win); } function openWin(url,w,h){ var win="toolbar=no,location=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=no,width=" + w + ",height=" + h; controlWindow=window.open(url,"",win); } &et=6A5EFA635696B2E574B7777CA522DEF18AC6B859B164CE6C8538D76BE9BA0D626F77FEBEA98E1DBC95FBAE25DA5EB92F9C9B8FB0737A8A08BBBDEC05D8C15B3B187C4B48B4955DA29013EBC6BBBDCF696BD36D4A0D59E73771126E59E7E91273012D03C6748985E4&pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=AD36F34DDC3BA7B0&jid=&yid=B6351343F4791CA3&aid=&vid=&iid=38B194292C032A66&sid=002786F01A86D891&eid=1D01216AD76577EC&fileno=20190311&flag=1&is_more=0"> var my_pcid="A9DB1C13C87CE289EA38239A9433C9DC"; var my_cid="AD36F34DDC3BA7B0"; var my_jid=""; var my_yid="B6351343F4791CA3"; var my_aid="";