• 高级搜索
  • 进入期刊界搜索引擎>>
孙德春,赵子健,高磊,孙健,杨舸,李晓文,李盛钰.量子降脂仪对高脂血症大鼠血脂的影响及其机制[J].中国动脉硬化杂志,2019,(3):211~215
量子降脂仪对高脂血症大鼠血脂的影响及其机制
Effect and mechanism of quantum lipid-lowering instrument on blood lipid in rats with hyperlipidemia
投稿时间:2018-09-20  修订日期:2018-12-10
DOI:
中文关键词:  高脂血症  量子降脂仪  胆固醇调节元件结合蛋白2
英文关键词:hyperlipidemia  quantum lipid-lowering instrument  SREBP-2
基金项目:吉林省科技厅项目(201603050YY,20160312019X);长春市科技局项目(16SS10)
作者单位E-mail
孙德春 中国科学院苏州生物医学工程技术研究所,江苏省苏州市215163 e-mail为dechunsun@xianyingkeji.com,e-mail为lisy720@126.com 
赵子健 吉林省农业科学院农产品加工研究所,吉林省长春市130033  
高磊 吉林省农业科学院农产品加工研究所,吉林省长春市130033  
孙健 中国科学院苏州生物医学工程技术研究所,江苏省苏州市215163  
杨舸 吉林省农业科学院农产品加工研究所,吉林省长春市130033  
李晓文 中国科学院苏州生物医学工程技术研究所,江苏省苏州市215163  
李盛钰 吉林省农业科学院农产品加工研究所,吉林省长春市130033 e-mail为dechunsun@xianyingkeji.com,e-mail为lisy720@126.com 
摘要点击次数: 29
全文下载次数: 23
中文摘要:
      目的 观察量子降脂仪对高脂血症模型大鼠的降血脂作用并探讨其机制。方法 以高脂饲料和10%果糖自由饮水建立无特定病原体动物(SPF)级大鼠高脂血症模型。量子降脂仪输出功率强度为70 μW/(cm2·min),每天治疗1~2次,治疗时间为每次5~10 min。采用Elisa试剂盒检测血清中血脂水平,Western blot方法检测脂类代谢和炎症通路关键蛋白表达水平的变化。结果 量子降脂仪明显改善由高脂血症引起的的血脂代谢紊乱、调节血脂平衡、降低炎症状态、缓解肝功能损伤、缓解氧化损伤、提高脂肪代谢相关酶的活性、抑制脂肪酸合成酶的活性。Western blot结果显示,量子降脂仪通过调节核因子κB(NF-κB)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)蛋白的表达水平,缓解机体慢性炎症;通过调节过氧化体增殖物激活型受体α(PPARα)蛋白的表达水平促进机体脂质代谢;通过调节胆固醇调节元件结合蛋白2(SREBP-2)通路,促进低密度脂蛋白受体(LDLR)蛋白表达,缓解脂质代谢紊乱,调节机体高胆固醇和高甘油三酯水平。结论 量子降脂仪具有明显降血脂作用,可作为降血脂医疗器械辅助应用于临床。
英文摘要:
      Aim To investigate the effects and mechanisms of quantum lipid-lowering instrument on lipid regulation. Methods High fat diet and 10% fructose were used to establish a rat model of hyperlipidemia. The output power of the quantum lipid-lowering instrument was 70 μW/cm2, and the treatment time was 5~10 minutes for each time,1~2 times a day. Elisa kit was used to detect serum lipid levels and Western blot was used to measure the expressions of key protein in lipid metabolic and inflammatory pathways. Results Quantum lipid-lowering instrument can improve the disorder of blood lipid metabolism, regulate blood lipid balance, reduce inflammation, alleviate liver function damage, alleviate oxidative damage, increase the activity of lipid metabolism-related enzymes, and inhibit the activity of fatty acid synthase which is caused by hyperlipidemia. Western blot showed that Quantum lipid-lowering instrument could alleviate inflammation by regulating the expression levels of nuclear factor κB (NF-κB), tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6);modulate the expression of peroxisome proliferators-activated receptors α (PPARα) which could improve lipid metabolism;regulate the sterol-regulatory element binding proteins 2 (SREBP-2) pathway to increase low-density lipoprotein receptor (LDLR) protein expression, alleviate lipid metabolism disorders, and regulate cholesterol and triglyceride levels. Conclusion Quantum lipid-lowering instrument has obvious effect of lipid regulation, and can be used as an assisted clinical instrument for lowering lipid.
查看全文  查看/发表评论  下载PDF阅读器
关闭




您是本站第 7228001位访问者
版权所有:中国动脉硬化杂志  湘ICP备11008367号
主管单位:中国科学技术协会  主办单位:中国病理生理学会、南华大学
电话:0734-8160765  传真:0734-8160523  E-mail:dmzzbjb@163.net  网址:www.dmzzbjb.net
function PdfOpen(url){ var win="toolbar=no,location=no,directories=no,status=yes,menubar=yes,scrollbars=yes,resizable=yes"; window.open(url,"",win); } function openWin(url,w,h){ var win="toolbar=no,location=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=no,width=" + w + ",height=" + h; controlWindow=window.open(url,"",win); } &et=A0058C3448EF466947CC11C8B8C9B1869B37DE16DE11CB10DB0A77007C3989360EA6693FF75C2D0A48005B92B5A709FDB5FA3A64EFB117D2A8CF0D8FF8D112AE71BAC15ED511C0BA605BCDA8A4D51F90F81DB25047B2EB5C08085053CFDD9F16C35452009586EC75&pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=AD36F34DDC3BA7B0&jid=&yid=B6351343F4791CA3&aid=&vid=&iid=38B194292C032A66&sid=CC0ECB9C52F1B85F&eid=1B64850025D0BBBE&fileno=20190305&flag=1&is_more=0"> var my_pcid="A9DB1C13C87CE289EA38239A9433C9DC"; var my_cid="AD36F34DDC3BA7B0"; var my_jid=""; var my_yid="B6351343F4791CA3"; var my_aid="";