With the popularization of CT angiography, magnetic resonance angiography and digital subtraction angiography (DSA), the detection rate of intracranial artery stenosis is improved. Intracranial artery stenosis causes a diversity of clinical manifestation. For example, asymptomatic, dizziness and stroke and so on. As a multi-etiological disease, its pathogenesis is complex, and the recurrence rate of ischemic stroke is high. Intracranial artery stenosis have different distribution in age, sex and race. This may suggest that genetic factors play an important role. At present, some progress has been made in genetic factors of intracranial artery stenosis.