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ATP敏感性钾通道:介导心肌缺血再灌注损伤的新靶点
作者:
作者单位:

(1.内蒙古科技大学包头医学院研究生学院,;2.内蒙古科技大学包头医学院第一附属医院心内一科,内蒙古包头市 014040)

作者简介:

曹洪帅,硕士研究生,研究方向为心血管内科学,E-mail为15369327582@163.com。

基金项目:

内蒙古自治区自然科学基金项目(2016MS08101)


ATP-sensitive potassium channel:New target for mediating myocardial ischemia reperfusion injury
Author:
Affiliation:

1.Graduate School, Baotou Medical College, Inner Mongolia University of Science and Technology, ;2.Department of Cardiology, First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia 014040, China)

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    摘要:

    缺血心肌在恢复灌注后,病情反而加重,引起心肌超微结构的不可逆性改变,造成心肌功能、代谢及电生理方面的进一步损伤的现象,称为心肌缺血再灌注损伤(MIRI)。细胞凋亡与大部分心血管疾病的发生发展密切相关,在众多心脏疾病如心力衰竭、心肌梗死、心律失常、心肌病等中都存在细胞凋亡。细胞凋亡在MIRI进展中发挥着重要作用。ATP敏感性钾通道(KATP)参与细胞的多种活动和功能调节,具有扩张血管和心肌保护的作用,日益成为关注的热点,但该通道调控细胞凋亡的详尽机制尚未明确。本文综述了KATP介导MIRI作用及可能机制的近期研究进展。

    Abstract:

    After reperfusion, the condition of the ischemic myocardium aggravates, which causes the irreversible change of myocardium ultrastructure, resulting in the further damage of cardiac function, metabolism and electrophysiology; It is called myocardial ischemia reperfusion injury (MIRI). Cell apoptosis is closely related to the development of most cardiovascular diseases. There is cell apoptosis in many heart diseases, such as heart failure, myocardial infarction, arrhythmia, cardiomyopathy and so on. Cell poptosis plays an important role in the progress of MIRI. ATP-sensitive potassium channel (KATP) participates in a variety of activity and function regulation of cells, and it has the role of dilating blood vessels and myocardial protection, so increasingly becoming a hot spot of concern. However, the detailed mechanism of KATP regulating cell apoptosis is not yet clear. This review summarizes the recent progress in the role and possible mechanisms of KATP mediated MIRI.

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引用本文

曹洪帅,蔺雪峰,董昊晨,韩轩茂. ATP敏感性钾通道:介导心肌缺血再灌注损伤的新靶点[J].中国动脉硬化杂志,2018,26(6):644~648.

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  • 收稿日期:2017-12-19
  • 最后修改日期:2018-01-05
  • 在线发布日期: 2018-07-10

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