Arteriosclerosis obliterans of lower extremity (ASO) is caused by atherosclerosis and characterized by arterial stenosis and occlusion. Endovascular stenting as a minimally invasive, safe and effective method, has been widely used in the femoral artery and popliteal artery ASO treatment. However, the incidence of restenosis (ISR) in the stent is high, which seriously affects the clinical prognosis of the patients. Stent restenosis remains a major problem in stent use. In this paper, the mechanism, risk factors and the latest treatment progress of restenosis after stent implantation are reviewed, which is of significance to the prevention and treatment of ISR.