Aim To explore the circulating levels of long intergenic non-coding RNA predicting cardiac remodeling (LIPCAR) in patients with chronic heart failure (CHF) and combined renal insufficiency. Methods Venous blood samples were collected from 80 control subjects, 188 patients with CHF, including 80 patients with renal insufficiency, LIPCAR was evaluated by real-time PCR. Results The expression of LIPCAR was significantly different between the control group and the CHF group (1.08±0.28 vs.0.79±0.31, P＜0.01). In addition, the subgroup analysis of CHF showed that the patients complicated with renal insufficiency exhibited a tendency of lower levels of LIPCAR. Furthermore, LIPCAR was negatively correlated with NT-proBNP, whereas positively correlated with ejection fraction (P＜0.01). AUC was 0.777(95%CI＝0.720～0.835) for LIPCAR to judge CHF. Conclusion Circulating LIPCAR levels were significantly downregulated in patients with CHF, especially in those complicated with renal insufficiency. It may be valuable as a potential biomarker for CHF.