The incidence of hypertension has increased year by year, high blood pressure and the resulting target organ damage has become one of the main killers of human health. Early diagnosis and treatment of hypertension and its target organ damage have important implications for improving the prognosis of the patients and reducing morbidity and mortality. With the increase in awareness of the pathophysiology of hypertension-arteriosclerosis-target organ damage, the degree of concern for atherosclerosis is also increasing. Studies have shown that arteriosclerosis test ambulatory arterial stiffness index (AASI) and arteriosclerosis target organ damage is closely related. This review summarizes the advances in the clinical application of AASI in hypertensive patients.