Atherosclerosis is a chronic inflammatory disease related to dyslipidemia, hypertension, smoking, obesity and other factors. Necroptosis is a regulated form of necrosis, playing a major role in pathological process of inflammation. Recent studies have suggested that necroptosis contributes to advanced atherosclerosis, which may provide a framework for understanding the clinical benefits and therapeutic potential to atherosclerosis of researching and manipulating necroptosis.