Aim To investigate the relativity of interleukin-6 gene－572C/G polymorphism with combined hyperlipidemia in Zunyi Han Nationality. Methods －572C/G polymorphism of 100 combined hyperlipidemia patients and 100 healthy individuals were tested by sequencing after polymerase chain reaction. Results Age, gender and blood sugar had no statistical differences between patients group and normal group, but blood lipid index of combined hyperlipidemia patients was higher than healthy individuals(P<0.05). The genotype frequency and allele gene frequency of IL-6 gene －572C/G showed no correlation between patients group and normal groups (P>0.05). Total cholesterol (TC), low density lipoprotein cholesterol (LDLC), triglyceride(TG)/high density lipoprotein cholesterol (HDLC) and TC/HDLC were different between CC and CG+GG genotype in the normal group(P<0.05); others had no differences among the two groups. Conclusion There was no relativity between IL-6 gene －572C/G polymorphism and combined hyperlipidemia in Zunyi Han Nationality. The －572G gene was not an independent risk factor for combined hyperlipidemia.