Lipoprotein lipase (LPL) degradation is one of the important ways to regulate the level of LPL. Recently, it has been found that LPL degradation is regulated by a variety of related proteins, the process of LPL degradation mainly includes two parts:intracellular degradation and extracellular degradation. The intracellular degradation of LPL means a large amount of newborn LPL which were transferred to the lysosome for degradation via the related proteins. The extracellular degradation of LPL means mature LPL which were re-uptaked or transported into the cell under the action of the related proteins, and then gathered into lysosomal for degradation. This article will review the LPL in the process of LPL protein synthesis, transportation and biological functions, and then elucidate the relationship between its degradation and metabolic syndrome.