Aim To investigate the correlation between helicobacter pylori infection and coronary heart disease as well as heme oxygenase-1 (HO-1). Methods According to the results of coronary angiography, the patients were divided into control group (n＝143) and coronary heart disease group (n＝149), according to the number of vessels involved, coronary heart disease group was subdivided into one-vessel group (n＝38), two-vessel group (n＝46), multi-vessel group (n＝65). All the patients underwent ¹³C-breath test, helicobacter pylori antibody and plasma HO-1 determination, at the same time, the patien’s case history was collected, serum uric acid, blood glucose, low density lipoprotein, high sensitivity C-reactive protein (hs-CRP) and glycosylated hemoglobin were detected. The correlation between helicobacter pylori infection and plasma HO-1 and coronary heart disease were evaluated. Results There were significant difference in smoking, age, low density lipoprotein (LDL), hs-CRP, homocysteine (Hcy) in the two groups. Helicobacter pylori infection and Gensini’s score in coronary heart disease group were significantly higher than those in control group, while plasma HO-1 were significantly lower (P＜0.05). Helicobacter pylori infection and Gensini’s score were significantly increased with the number of vessels involved, while plasma HO-1 were significantly decreased with the number of vessels involved (P＜0.05). Helicobacter pylori infection was positively correlated with the Gensini’s score (r＝0.869, P＜0.01), and plasma HO-1 was negatively correlated with the Gensini’s score (r＝－0952, P＜0.01). Helicobacter pylori infection were negatively correlated with HO-1 (r＝－0.858, P＜0.01). Conclusion Helicobacter pylori infection and plasma HO-1 have some predictive value to coronary heart disease.