Aim To explore the influence of brachial-ankle pulse wave velocity (baPWV) on the urine protein.Methods A total of 5440 participants who were aged over 40 without previous stroke, transient ischemic attack (TIA) and myocardial infarction were randomly selected from serving and retired workers of Tangshan Kailuan Company in 2006-2007 health examination, among which 5012 participants with integrated data were recruited into the study. Urine protein and baPWV were detected. Grouped baPWV using quartile group. The influence of baPWV on urine protein was analyzed by Logistic regression. Results Compared with the first quartile group, baPWV was a risk factor for positive urine protein, OR values were 0.778 (95%CI was 0.463～1.309), 1.323 (95%CI was 0.834～2.096) and 3.172 (95%CI was 2.122～4.741); and adjustment for age, sex, TC, TG, HDLC, LDLC, DBP, SBP, FBG, smoking, and drinking, similar results were obtained, OR values were 0.663 (95%CI was 0.424～1.036), 0.977 (95%CI was 0.640～1.491) and 1.682 (95%CI was 1.073～2.637). Conclusion The increase of baPWV was correlated with urine protein. The increase of baPWV was a risk factor for positive urine protein.