Aim To analyse the value of application and influence factors of pulse wave velocity （PWV）. Methods A total of 164 patients were divided into four groups: normal group, hypertensive group（HP）, coronary heart disease group（CHD） and coronary heart disease with hypertensive group（CHD+HP）. All patients were underwent coronary angiography（CAG）. Meanwhile, PWV were measured by invasive methods. Other baseline data, such as gender, age, height, weight and blood lipid, uric acid, creatinine and homocysteine were measured at the same time. One-way ANOVA, multiple linear regression and q tests were used in this study. Results （1） There were significant difference in carotid-femoral pulse wave velocity（CFPWV） and carotid-dorsal artery of foot pulse wave velocity （CDPWV） among those four groups. CFPWV and CDPWV of those three groups were significantly higher than that of normal group. There was no significant difference in carotid-radial pulse wave velocity （CRPWV） among those four groups. （2）There was no significantly difference in CFPWV and CDPWV between HP group and pure CHD group. CFPWV of CHD+HP group was significant higher than that of HP group and pure CHD group（P<0.05）. CDPWV of CHD+HP group was significantly higher than that of pure CHD group（P<0.05）. （3）There was significant difference in CFPWV, CDPWV and CFPWV for within-group. （4）Multiple stepwise linear regression analysis found that heart rate, homocysteine, high density lipoprotein cholesterol （HDLC） and pulse pressure（PP） were predisposed factors for CFPWV, while HDLC and mean artery pressure（MAP） were predisposed factors for CDPWV. Conclusion PWV was higher in patients with hypertension and coronary heart disease than that of normal people. Vascular injury of patients with CHD complicated HP is significantly more severe than that of HP or pure CHD. CFPWV has higher clinical value in daily practice. Heart rate, blood pressure, plasma homocysteine and HDLC were the influence factors of the PWV. PWV provides reliable reference index for early prevention, diagnosis and treatment of hypertension and coronary heart disease.