Aim To investigate correlation between renal function and severity of coronary lesions and ACS.Methods A total of 344 patients treated in the Second Hospital of Shanxi Medical University who were diagnosed by coronary angiography were studied. The patients were divided into 3 groups:Unstable Angina （UA） group,n165Acute Myocardial Infarction （AMI） group,n93 and control group of the patients with CAG showing no evidence of coronary artery disease,n86. Total cholesterol （TC）,low density lipoprotein cholesterol（LDLC）,high denslity lipoprotein cholesterol （HDLC） were measured by enzymic method and lipoprotein a by immune turbidity method Serum creatinine by picric acid methodThe calculation method of eGFR was the aMDRD formulaThe method of evaluating the severity of coronary lesions was the modified Gensini. Results （1）The Scr of Control group ,UA group and AMI group were （64.32±10.53）μmol/L，70.54±13.42 μmol/L and 85.47±13.52 μmol/L（the Control vs AMI group ,P<0.05） The eGFR ［mL/（ min·1.73 m² ）］ of Control group ,UA group and AMI group were 113.52±17.47 mL/（min·1.73 m² ），88.54±14.53 mL/（min·1.73 m² ） and 80.53±13.63 mL/（min·1.73 m²）（all P<0.05）The Gensini scores of the UA group and AMI group were 40.54±23.45 and 54.78±23.78（P<0.05）. （2）There was a negative corelation between eGFR and Gensini scores（r－0.507）LDLC（r0.865）,TC（r0.743） and Lp（a） （r0.221） were positively correlated with Gensini scores （all P<0.001） . （3） Multivariate logistic regression analysis （forward method） indicated that eGFR（OR0.249，95%CI 0.132～0.472，P<0.001）,LDLC（OR15.724，95%CI 8.042～30.732，P<0.001）and TC（OR7.402，95%CI 4.534～12.083，P<0.001）were interrelated with ACS. （4）Results of follow up:there was no statistical difference in follow up time,mortality,MACE,tking time of aspirin and clopidogrel,rehospitalization for angina.Conclusion There was a connection between renal function and ACS. The lower the eGFR the more serious the coronary lesions . eGFR was one of the independent risk factors for diagnosing ACS. Our study haven’t observed CKD affecting the short-term prognosis of PCI.