Aim To investigate the influential factors on stability of carotid plaques in patients with ischemic stroke （IS）. Methods 171 cases of ischemic stroke patients,were confirmed by color ultrasound diagnostic instrument check to make sure carotid artery plaques.According to the characteristics of magnetic resonance imaging （MRI）,the patients were divided into stable plaque group and unstable plaque group.Logistic regression model was used to estimate the risk factors influencing stability of carotid plaques. Results Of 171 patients,119 （69.59%） patients had unstable plaques and 152 （30.41%） patients had stable plaques.The levels of low density lipoproteins （LDL）,apolipoprotein A1 （ApoA1）,fasting blood glucose （FBG）,glycosylated hemoglobin （GHb）,uric acid （UA） and high-sensitive C-reactive protein （hs-CRP） in the unstable plaque group were higher than those in the stable plaque group.ApoA1 （OR＝3.92,95%CI 2.11～7.25,P＝0.000）,FBG （OR＝1.34,95%CI 1.06～1.69,P＝0.014）,UA （OR＝1.01,95%CI 1.00～1.01,P＝0.001） and hs-CRP （OR＝1.33,95%CI 1.09～1.62,P＝0.005）were independent risk factors of unstable plaques. Conclusions Ischemic stroke incidence rate is high in patients with unstable plaque.Unstability of carotid plaques is closely correlated with ApoA1,FBG,UA and hs-CRP.