Vascular calcification is a common complication in diabetic patients,which includes intimal calcification and medial calcification. Vascular calcification is usually progressive and a predictor of cardiovascular disease and all-cause mortality in these patients. Vascular calcification in diabetics is an active,highly regulated,cell-mediated process involved in various promotors and inhibitors. Various factors play a significant role in vascular calcification,including hyperglycemia,insulin resistance,kidney disease,inflammation,abnormal bone-associated protein,etc. There is no effective treatment for vascular calcification in diabetics at present. It is very important to evaluate and control risk factors of vascular calcification and provide preventive therapy for patients with diabetes.