早发冠心病患者理想心血管健康行为和因素研究
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Ideal Cardiovascular Health Behaviors and Factors in Patients with Premature Coronary Heart Disease
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    目的研究早发冠心病患者理想心血管健康行为和因素特点,以期为早发冠心病的一级预防提供资料。方法连续选择2013年1月至2013年9月于唐山工人医院心内科经冠状动脉造影首次确诊冠心病患者544例,排除冠心病阳性家族史61例,资料不全者24例。按患者年龄(男性≤55岁,女性≤65岁)分为早发冠心病组229例作为病例组,晚发冠心病组(男性>55岁,女性>65岁)208例作为对照组。利用病例对照研究方法,分析早发冠心病患者理想心血管健康行为和因素特点。结果①早发冠心病组的男性比例、收缩压、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯与晚发冠心病比较,差异无统计学意义(P>0.05)。早发冠心病组的空腹血糖、舒张压、总胆固醇、体质指数高于晚发冠心病组,差异有统计学意义(P<0.05)。②早发冠心病组在健康饮食比例、体育锻炼比例低于晚发冠心病组,在空腹血糖、吸烟、体质指数、总胆固醇、血压高于晚发冠心病组,差异有统计学意义(P<0.05)。③理想健康心血管行为和因素的Logistic回归分析得出:吸烟、血糖水平、体质指数的增加、健康饮食、体育锻炼的减少与早发冠心病的OR值(95%CI)分别为:1.46(1.02~2.28)、2.17(1.22~3.86)、2.59(1.68~4.00)、2.78(1.90~4.08)和3.68(2.54~5.34)。结论理想心血管健康行为和因素中吸烟、血糖、体质指数的增加、健康饮食和体育锻炼的减少可能是早发冠心病的危险因素。

    Abstract:

    Aim To explore the ideal cardiovascular health behaviors and factors in patients with premature coronary heart disease (CHD),in order to provide guideline for primary prevention of premature CHD and early targeted treatment.Methods A total of 544 patients diagnosed with CHD by coronary angiography were selected from department of cardiology,Tangshan worker’s hospital from January 2013 to September 2013.We excluded subjects with a family history of CHD (n61) and those who had missing data on health factors or health behaviors (n24).Based on age,the subjects were divided into two groups: 229 patients with premature CHD (male aged ≤55 years,female aged ≤65 years) served as the case group,while 208 patients with late-onset CHD (male>55,female>65 years) served as the control group.A case-control study was conducted to analyze the ideal cardiovascular health factors and health behaviors in patients with premature CHD,such as age,gender,body mass index (BMI),history of smoking and drinking,healthy dietary intake,physical activity,history of hypertension,diabetes and dyslipidemia,family history of CHD and so on.Results ①As for percentage of males,systolic blood pressure,high density lipoprotein cholesterol (HDLC),low density lipoprotein cholesterol (LDLC) and triglyceride (TG),no statistically significant difference was found between the two groups (P>0.05).Total cholesterol levels,diastolic blood pressure,BMI and fasting blood glucose in premature CHD group were higher than those in the control group,which was significantly different (P<0.05)②The proportion of healthy dietary intake and physical activity was lower in premature CHD group,compared with that in late-onset CHD group (P<0.05)③Multiple logistic regression analysis on ideal cardiovascular health behaviors and factors showed that cigarette smoking,elevated fasting blood glucose and higher BMI as well as inadequate healthy dietary intake and physical inactivity were associated with premature CHD,and OR values were 1.46 (95%CI 1.02~2.28),2.17 (95%CI 1.22~3.86),2.59 (95%CI 1.68~4.00),2.78 (95%CI 1.90~4.08) and 3.68 (95%CI 2.54~5.34),respectively.Conclusion Cigarette smoking,elevated fasting blood glucose,BMI,inadequate healthy diet and physical inactivity may be associated with the incidence of premature CHD.

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韩全乐,刘晓堃,张琦,王金艳,刘晓明,张庆华,刘长青.早发冠心病患者理想心血管健康行为和因素研究[J].中国动脉硬化杂志,2014,22(12):1268~1272.

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  • 收稿日期:2014-05-16
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