Aim To investigate the efficacy of the double coated compound drug-eluting stent of As₂O₃ and CD133⁺antibody to repair vascular endotelium and prevent smooth musle cell poliferation. Methods 65 China miniature pigs were fed with no-fat diet for 4 weeks, then divided into 3 groups: sham group, stent implantation group, ballon injury group. Four weeks later, coronary evaluting with OCT was performed, the plasma TFPI-2 level was checked and coronary artery tissue was used for immunohistology analysis. Results The OCT images showed that the coronary plaque enlarged significantly,endothelium and fibrous cap obviously thickened in ballon injury group, and the sham group was normal,the group B was found between the two. The coronary intima/media thickness ratio was 2.12±0.74 in balloon group,1.74±0.66 in stent implantation group and 1.52±0.47 in sham group. Intima/media area ratio was 2.23±0.72 in balloon group, 2.01±0.56 in stent implantation group and 1.89±0.27 in sham group . The plasma TFPI-2 level: sham group, stent implantation group, ballon injury group was 135.2±22.6 μg/L，127.2±23.4μg/L，52.4±22.6 μg/L respectively The sham group and stent implantation group were similar, but the balloon injury group were significantly decreased, the difference was statistically significant （P<0.01）. Western blot results: TIFI-2 and β -actin ratio of group sham group, stent implantation group, ballon injury group were 2.45 ± 0.22, 2.22 ± 0.26, 1.27 ± 0.33 respectively TFPI-2 in normal arterial tissues expressed less The expression level of TFPI-2 in double coated compound drug-eluting stent and sham group were similar with no significant difference （P>0.05）. Balloon injury group expression was significantly decreased, the difference was statistically significant （P<0.01）. Conclusion The double coated compound drug-eluting stent could promote the endothelium to produce TPFI-2，enhance the plasma TFPI-2 level, and then reduce the formation of stent thrombosis in possible. Otherwise,it could decrease in-stent intimal hyperplasia.