Aim To study the effect of fluvastatin on cardiac remodeling and cardiac function， and to investigate the effect of matrix metalloproteinase-9 （MMP-9） and MMP-10. Methods 36 Wistar rats were randomly divided into acute myocardial infarction （AMI） group,AMI+fluvastatin group and the sham-operated group. AMI was established by ligation of the anterior descending coronary artery in rats, fluvastatin was fed to AMI+ fluvastatin group by 20 mg/（kg·d） for 6 weeks. After 6 weeks treatment, then the hemodynamic parameters and mass index of left ventricular and the expression of MMP-9 and MMP-10 were detected. Results Compared with the sham-operated group, left ventricular systolic pressure（LVSP） and the maximal rate of rise and fall （±dp/dt_max） of left ventricular pressure in the AMI group and AMI+fluvastatin group were all decreased（P<0.05）, moreover,these indexes decreased significantly in AMI group than those in AMI+fluvastatin group（P<0.05）. Compared with the sham-operated group, left ventricular end-diastolic diameter （LVEDD）, left ventricular end systolic diameter （LVESD）, left ventricular mass index （LVMI）, MMP-9, MMP-10 were significantly increased in the AMI group and AMI+fluvastatin group moreover,these indexes decreased in AMI+ fluvastatin group than those in AMI group（P< 0.05）. Conclusion Fluvastatin could prevent the cardiac remodeling， the mechanisms may be by reducing the levels of MMP-9 and MMP-10.