20748例健康体检对象肱踝脉搏波传导速度的分析
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国家“十二五”科技支撑计划(2012BAI37B04);全军“十一五”计划保健专项课题(10BJZ18)


Analysis of Brachial-ankle Pulse Wave Velocity for 20748 Subjects Undergoing Physical Examination
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    摘要:

    目的 研究健康体检人群的肱踝脉搏波传导速度(BaPWV)的分布特点及其与临床指标的相关性。方法 将2009年5月至2012年2月在解放军总医院健康医学中心进行健康体检的人群作为研究人群,记录性别、年龄、有无高血压病史、吸烟及饮酒情况;测量血压,计算脉压;用人体成分分析仪测量体重、身高,计算体质指数;抽血化验空腹血糖、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血尿酸、高敏C反应蛋白、同型半胱氨酸、血清肌酐、血红蛋白;应用动脉硬化检测仪测量BaPWV。将完成本研究所涉及的全部检查项目者共计20748例作为研究对象,按性别、吸烟与否、饮酒情况等进行分组,分析研究对象中BaPWV的分布特点及其与以上指标的关系。结果 (1)将BaPWV≥1400 cm/s作为动脉硬化的界值,发现不同年龄组的体检人群都有BaPWV的异常检出,随着年龄的增大BaPWV平均值及异常检出率增加。(2)男性人群的BaPWV略高于女性人群;吸烟者BaPWV均值高于不吸烟者;有高血压病史的研究人群的BaPWV均值明显高于无高血压病史者;饮酒习惯不同,BaPWV也存在显著性差异,其中偶尔饮酒者BaPWV反而较低。(3)Logistic回归分析显示,年龄、高血压病史、吸烟、体质指数、脉压、空腹血糖、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高敏C反应蛋白、同型半胱氨酸、血清肌酐、血尿酸、血红蛋白、饮酒等因素都是BaPWV异常的显著影响因素。结论 BaPWV的分布特点符合人群中动脉硬化的分布特点,且其影响因素与传统的动脉硬化影响因素基本一致。作为无创性检查指标之一,BaPWV可以客观地反映动脉硬化的程度,从而为健康干预提供依据。

    Abstract:

    Aim To investigate the distribution characteristics of brachial-ankle pulse wave velocity (BaPWV) and its correlation with the clinical indicators in crowd undergoing physical examination. Methods The subjects from the Health Medical Center of Chinese PLA General Hospital from May 2009 to February 2012 were enrolled as the object of study. The gender, age, hypertension history, smoking and alcohol status were recorded. The blood pressure was measured and the pulse pressure (PP) was calculated The weight and height were measured on a human body composition analyzer and the body mass index (BMI) was obtained The fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC), blood uric acid (BUA), high sensitivity C-reactive protein (hs-CRP), homocysteine (Hcy), serum creatinine (SCr), hemoglobin (Hb) concentration were tested by drawing blood The BaPWV was measured on an arteriosclerosis detector. The total 20748 subjects undergoing all the inspection items related to this investigation were the object of study. The distribution characteristics of BaPWV of the subjects and its relationship with the above indices were analyzed. Results (1)The value of BaPWV≥1400 cm/s is taken as the critical point of arteriosclerosis. It was found that abnormal BaPWV data were observed for varying age groups with both the average BaPWV and abnormal detection rate rising with age. (2)The values of BaPWV of the male are slightly higher than those of the female The average value of BaPWV for smokers is higher than that of non-smokers The average value of BaPWV for subjects with hypertension history is markedly higher than that of subjects with normal blood pressure For subjects with varying alcohol drinking habits there exists significant differences in BaPWV and occasional alcohol drinkers showed, however, relatively low BaPWV. (3) Logistic regression analysis indicates that the age, hypertension history, smoking status, BMI, PP, FBG, TG, TC, LDLC, hs-CRP, Hcy, SCr, BUA, Hb and alcohol drinking etc.are all significant factors related to abnormal BaPWV. Conclusions The distribution characteristics of BaPWV is coincident with that of arteriosclerosis in adult population and its influencing factors is basically in accord with traditional factors related to arteriosclerosis. As one of non-invasive physical examination indicators, BaPWV can objectively reflect the degree of arteriosclerosis, thus providing the dependence for health intervention.

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樊广渊,郑延松,陈志来,黄建华,李 杨,曾 强.20748例健康体检对象肱踝脉搏波传导速度的分析[J].中国动脉硬化杂志,2014,22(8):803~807.

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  • 收稿日期:2014-02-23
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