Liver X receptors （LXRs） belong to the nuclear receptor superfamily, contain two kinds of isoforms including LXRα and LXRβ. It not only regulates the expression of various kinds of target genes in the process of reverse cholesterol transport, promotes reverse cholesterol transport in vivo, but also plays an important role in the regulation of the expression of inflammatory cytokines and inflammatory mediators. Therefore, this paper mainly recount that LXR is the common platform of reverse cholesterol transport and inflammation.