Aim To examine the association between rs4420638 polymorphism in Apo C-1 gene and carotid intima-media thickness （IMT）and plaques. Methods A community-based cross-setional survey was carried out in 1345 participants free of myocardial infarction, stroke and cancer （male 457, female 457, aged 41 to 78 years） in Beijing. Standard methods were used for collecting data on cardiovascular disease risk factors. Carotid IMT and plaques were detected with color doppler ultrasound instrument. ApoC-1 rs4420638 polymorphism was detected with SNaPshot method. Results Participants were divided into AA, GA + GG genotype groups by the dominant model. The carriers with GA + GG genotype had significantly lower plasma hs-CRP levels than that of the carriers with AA genotype （P< 0.05）. There was no significantly difference in lipid profile （TC, TG, LDLC and HDLC） between the two groups（P>0.05）. In univariate and multivariate variance analysis, there was no significant difference in carotid intima-media thickness between the two groups （P>0.05）. By univariate and logistic regression analysis （adjustment for age, sex；age,sex and traditional risk factors）, GA + GG positive rate of carotid plaques was significantly lower than AA group （P0.02）, but after adjusted hs-CRP on the basic multivariate model, there was no significant difference （P>0.05）. Conclusions ApoC-1 gene rs4420638 was associated with hs-CRP,but not with carotid IMT or positive rate of carotid plaques （after adjusted plasma hs-CRP）.