Aim To investigate the acute myocardial infarction （AMI） and the clinical characteristics associated with hyperglycemia and coronary artery angiography. Methods 58 cases of acute myocardial infarction patients were divided into two groups: stress hyperglycemia AMI group: 30 cases, with stress hyperglycemia （blood sugar≥7.0 mmol/L） normal blood glucose AMI group: 28 cases, with normal blood glucose （blood sugar≤6.1 mmol/L）. Clinical characteristics of two groups were compared. Results Comparing stress hyperglycemia AMI group and normal AMI group, in the former group the age is older, and the heart function is not complete, no reflow phenomenon is high, the case fatality rate is high. Three branch lesion and diffuse lesions are significantly different between stress hyperglycemia AMI group and normal blood glucose AMI group. Conclusion AMI patients combined with stress hyperglycemia had greater age, poor heart function, lesions associated with more anterior descending branch or the proximal right coronary artery, and high hospital mortality.