Epicardial adipose tissue is a part of visceral tissue deposited around the heart, especially around coronary arteries, which can express many kinds of adipokines participating in the occurrence and development of atherosclerosis. Recently it has been confirmed these adipokine can also cause angiogenesis within the coronary atherosclerotic plaque. These neovessels have very strong permeability, which can improve the condition of local hypoxia new blood vessels, on the other hand, may promote the plaque’s progression and lead to its probability of instability increase. Thus, by studying the molecular mechanism of adipokines promoting angiogenesis, the inhibition of angiogenesis in the plaque to enhance the stability of the plaque can become a new target for therapy of coronary heart disease in the future.