Aim To explore the association of －455G/A polymorphisms of β-fibrinogen gene with coronary heart disease. Methods 240 coronary heart disease patients and 240 normal people were involved. －455G/A polymorphisms of β-fibrinogen gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism （PCR-PFLP），and the plasma fibrinogen was determined. Results （1）The frequency of GA/AA genotype and A-allele （45.4% and 25.2%） was significantly higher in coronary heart disease group compared with their controls（26.7% and 15.2%）（P<0.05）. （2）The level of fibrinogen of each genotype in coronary heart disease group was significantly higher than the same genotype of the control group In each group，the level of fibrinogen of patients with GA genotype was significantly higher than those of patients with GG genotype,the level of fibrinogen of patients with AA genotype was significantly higher than those of patients with GA genotype（P<0.05）. Conclusion β-fibrinogen gene －455G/A polymorphism may be related to coronary heart disease，the A-allele may be the risk genetic factor for coronary heart disease，and maybe have contact with coronary heart disease by influencing the level of fibrinogen.