Aim To observe the influence of aspirin combined with atorvastatin on arterial stiffness in the hypertensive patients with complicating diabetes and early renal damage. Methods The hypertensive patients with complicating diabetes and early renal damage （n＝80） were randomly divided into the aspirin group （treated with 100 mg/d bayaspirin） and combination group （treated with 100 mg/d bayaspirin and 20 mg/d atorvastatin）. The levels of blood lipids, urinary albumin, β₂-microglobulin （β₂-MG）, urinary albumin excretion rate （UAER）, cardio-ankle vascular index （CAVI） and ankle-brachial index （ABI） were detected before the treatment and 20 weeks after the treatment respectively. Results （1）Blood lipids: the levels of total cholesterol （TC） and low density lipoprotein cholesterol （LDLC） in two groups were lower than those before the treatment （P<0.05 and P<0.01）. The TC level was lower in the combination group than that in the aspirin group （P<0.05） after 20 weeks. （2）Arterial stiffness: the indexes of CAVI （12.67±1.40 vs 11.20±0.87, 11.64±1.28 vs 9.58±1.04） increased and ABI （0.87±0.12 vs 0.98±0.11, 0.88±0.40 vs 1.06±0.10） in two groups were decreased significantly （all P<0.05） after the treatment. After 20 weeks the index changes of CAVI and ABI were more significant （all P<0.05）. （3）Urine microprotein: the difference in the levels of urinary albumin, β₂-MG and UAER was not statistically significant in the aspirin group, but decreased in the combination group with statistical significance after the treatment, and compared to the aspirin group after the treatment, the decrease of urine microprotein was statistically significant （13.30±2.87 mg/L vs 15.70±3.73 mg/L, 2.15±1.29 mg/L vs 3.13±0.38 mg/L, 20.02±7.62 μg/min vs 23.13±7.60 μg/min, all P<0.05）. （4）In multiple linear regression model, CAVI, ABI, UAER were all significantly associated with blood pressure and plasma glucose. Conclusion Aspirin combined with atorvastatin can decrease the urine microprotein and improve the arterial stiffness in hypertensive patients with complicating diabetes and early renal damage.