AimTo explore how to reduce the incidence of coronary artery in-stent restenosis (ISR) via analysis of the related factors to ISR.Methods100 cases with coronary artery ISR and 100 cases without coronary artery ISR were selected.We analyzed the related factors affecting the coronary ISR by comparing the coronary heart disease risk factors and the coronary stent situations between the two groups of patients, and finally obtained the relevant intensity order for related factors by Logistic regression analysis.ResultsSignificant differences (P＜0.05) were shown both in smoking, blood pressure, blood sugar, total cholesterol, low density lipoprotein cholesterol, and in the diameter, length, location and quantity of stents between two groups with or without coronary ISR; Among the acute myocardial infarction (AMI) patients, significant differences (P＜0.05) were also shown in no application of Ⅱb/Ⅲa receptor antagonist and elevated level of C-reactive protein between two groups.Logistic regression analysis showed that coronary ISR had a strong correlation with 2 h postprandial blood glucose and smoking; The relevant intensity of coronary stents situation to coronary ISR showed: many pieces of stents ＞ stent diameter ＞ stent length ＞ stent location.ConclusionDiabetes, smoking, hypertension, hyperlipidemia, multivessel coronary lesions, severe stenosis, acute myocardial infarction patients without application of platelet Ⅱb/Ⅲa receptor antagonist, elevated level of C-reactive protein are the important factors associated with coronary artery ISR.