It has been a consensus that diabetes is one of the causes of cardiovascular diseases. With the continued strengthening to control the blood glucose of patients, the incidence of hypoglycemia are increasing. The impact of hypoglycemia on the prognosis of cardiovascular diseases has attracted more attention. The paper reviews recent researches about the impact of hypoglycemia and intensive glycemic control on the prognosis of cardiovascular diseases and has discussed its pathophysiological mechanisms.