Aim To determine the correlation of the carotid-femoral pulse wave velocity （cfPWV） with plasma high molecular weight-adiponectin （HMW-ADP） level of dewelling persons. Methods 87 dewelling persons who underwent health examination in medical examination center were surveyed in this experiment. The clinical data of subjects contained age,gender,waistline,systolic blood pressure （SBP）,diastolic blood pressure （DBP）,hepatic function,renal function,high density lipoprotein cholesterol （HDLC）,low density lipoprotein cholesterol （LDLC）,triglyceride （TG）,total cholesterol （TC）,fasting blood glucose （FBG）,postprandial 2 hour plasma glucose （2hPG）,fasting C-peptide,plasma total adiponectin level,plasma HMW-ADP level,cfPWV,HOMA-IR,and body mass index （BMI）. All subjects were divided into two groups in which group A contained 21 cases （cfPWV < 9 m/s） and group B contained 66 cases （cfPWV≥9 m/s）. Results The difference of BMI,SBP,DBP,the serum levels of HDLC,LDLC,TG,TC,total-ADP,and HMW-ADP between the two groups had statistical significance （P<0.05）,however,no significant differences occurred in age,gender,total protein,globulin,albumin,total bilirubin（TBIL）,conjugated bilirubin（CB）,aspartate aminotransferase（AST）,alanine aminotransferase（ALT）,blood urea nitrogen（BUN）,serum creatinine （Scr）,serum uric acid（UA）,fasting blood glucose （FBG）,postprandial 2 hour plasma glucose（2hPG）,fasting C-peptide,fastinginsulin（FIN） and homeostasis model assessment of insulin resistance （HOMA-IR）（ P>0.05）. Multivariate regression analysis revealed that the serum levels of HMW-ADP,total-ADP,and HDLC were negatively correlated with cfPWV （OR＾0.011,0.019,0.125P0.011,0.012,0.015）,while SBP was positively correlated with cfPWV（OR＾1.046,P0.045）. Conclusions High levels of HMW-ADP and total-ADP in serum may be the protective factors for angiosclerosis.