AimTo evaluate the clinical applicability of high sensitivity-C reactive protein（hs-CRP）and free fatty acid （FFA） in atrial fibrillation (AF).MethodsThe 122 cases were divided into 3 groups as 41 persistant AF, 42 paroxysmal AF, and 39 healthy volunteers; the serum levels of hs-CRP and FFA were detected.ResultsThe levels of hs-CRP and FFA in patients of persistant AF and paroxysmal AF were significantly higher than those in the control group (P<0.01).And the above levels in persistant AF were significantly higher than those in paroxysmal AF (P<0.01).ConclusionThe increase of hs-CRP and FFA indicate inflammation and abnormal metabolism might promote the occurrence and development of AF.