AimTo analyze the different expression of lipid metabolism-related genes such as ApoB100, PPARα, LXRα and ABCA1 in wild type and LDLR-/-mouse.MethodsqRT-PCR and ELISA were used respectively to measure the mRNA abundances and protein expression after LDLR-/-mouse genotype detecting by multiple PCR.ResultsThe expression of ApoB100, PPARα were up-regulated both in mRNA and protein level (P<0.05) in LDLR-/-mouse comparing to wild type; The ABCA1 expression was down (P<0.01), and the drop in protein was more striking than in mRNA level.However, there was no significant difference in mRNA and protein expression for LXRα gene between wild type and LDLR-/-mouse.