AimTo investigate the effects of tetrahydroxystilbene glucoside (TSG) on monocyte chemoattractant protein-1 (MCP-1), intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) mRNA expression of human umbilical vein endothelial cells (HUVEC) injuored by homocysteine (Hcy).MethodsHUVEC were treated with different concentration of TSG for 2 hours then treated with Hcy.Cell nucleus damage was detected by Hoechst33342 stain.mRNA expression levels of MCP-1, ICAM-1 and VCAM-1 were detected by RT-qPCR.ResultsPreincubation with TSG could attenuate the nucleolus damage of HUVEC induced by Hcy.While TSG concentration is less than 10 μmol/L, TSG showed a concentration dependent in decreasing the damage of Hcy on HUVEC.TSG decreased MCP-1, ICAM-1 and VCAM-1 mRNA expression that were increased by Hcy in HUVEC.ConclusionMCP-1, ICAM-1 and VCAM-1 mRNA expressions which were increased by Hcy in HUVEC in vitro can be reduced by TSG