CXC ligand 16 (CXCL16) as a member of the chemokines family can act as the adhesion molecule，Chemokines and scavenger receptor.It promotes the adhesion of activated T lymphocytes to endothelial cell and the proliferation of smooth muscle cell.Besides，it facilitates the aggregation of antigen presenting cells(APC) to the inflammation location and increases uptake of ox-LDL by macrophage which then convert to foam cells.It also takes part in the occurrence and development of atherosclerosis，angiostenosis and inflammation.In conclusion，CXCL16 and its receptor are related to the occurrence， severity and prognosis of the circulation system disease，such as atherosclerosis，coronary disease，stroke.And it may act as a predictor of the occurrence of clinical diseases.