AimTo investigate the effects of puerarin on ventricular function and calcium levels in diabetic rats.MethodsForty SD rats were randomly divided into four groups: the control group, the diabetic model group, the puerarin low dose group and high dose group.The cardiac function, ventricular mass index, heart weight index and calcium levels were respectively measured.ResultsCompared with diabetic model group, in the puerarin low dose group and high dose group cardiac function was significantly improved, ventricular mass index, heart weight index and calcium levels were decreased, but the puerarin high doses group improved more significantly.ConclusionsPuerarin can improve cardiac function, ventricular mass index, heart weight index in diabetic rats, and its mechanism may be related to intracellular calcium levels.