AimTo observe the effects of soluble epoxide hydrolase inhibitors t-AUCB on the uptake and degradation of lipid in mouse macrophage.MethodsRAW264.7 mouse macrophage was cultured, then t-AUCB in various concentration(1, 10, 50 and 100 μmol/L) were added for 24 hours, or incubated with peroxisome proliferators activated receptor gamma (PPARγ) antagonist GW9662 (5 μmol/L).0 μmol/L t-AUCB treated group was taken as empty control.After then, the uptake and degradation of oxidized low density lipoprotein (ox-LDL) in cells were detected by radioligand assay.The mRNA and protein expression of CD36 were determined by real-time PCR and Western blot .Resultst-AUCB could dose-dependently increase the uptake and degradation of ox-LDL in mouse macrophage.After stimulated with 0, 1, 10, 50 and 100 μmol/L t-AUCB, the uptake level of ox-LDL were 414.96±46.71 μg/g, 519.54±47.7 μg/g, 629.04±37.97 μg/g,720.66± 48.58 μg/g, 881.57±68.44 μg/g, and the degradation of ox-LDL were 16180.23±967.28 μg/g, 17369.62±478.34 μg/g, 21794.85±689.36 μg/g, 27883.03±712.25 μg/g, 30194.61±635.71 μg/g.However, after incubation of GW9662, the uptake and degradation of ox-LDL with 100 μmol/L t-AUCB