Aim To investigate the characteristics of epicardial adipose tissue in type 2 diabetes patients with metabolic syndrome.Methods 120 type 2 diabetes patients were included.Anthropometric measurements including height,weight,waist circumference,hip circumference and blood pressure were taken.Fasting venous blood was obtained and fasting plasma glucose,glycation hemoglobin,triglyceride(TG) and high density lipoprotein cholesterol(HDLC) were measured.Body fat composition,lean and epicardial adipose tissue(EAT) were analyzed by dual-energy-X-ray absorptiometry and echocardiogram,respectively.Multivariate Logistic regression analysis was used to estimate the strength of association between EAT and various factors.Results Patients with MS had greater waist circumference,Waist-to-Hip Ration,triglyceride,total body fat,android fat deposition,EAT and prevalence of hypertension and coronary artery disease than patients without MS.Waist circumference,triglyceride and android fat deposition were independent risk factors for increased ETA,while HDLC was an independent protective factor.Conclusions Type 2 diabetes with metabolic syndrome patients have increased EAT,which is significantly associated with waist circumference,triglyceride,android fat deposition and HDLC.