Aim To compare the effects of probucol combined with atorvastatin and atorvastatin only on serum oxidized low density lipoprotein(ox-LDL)and ox-LDL antibodies(ox-LDL-Ab) levels.Methods Forty eight patients with coronary heart disease were assigned to atorvastatin only group(20 mg/d of atorvastatin,n=22) or combined therapeutic group(20 mg/d of atorvastatin and 1.0 g/d of probucol,n=26) in a randomized manner.Serum levels of ox-LDL and ox-LDL-Ab were detected before and after treatment.Results After treated with atorvastatin only and combined therapy the levels of serum LDL,ox-LDL,TC and TG were significantly decreased(P<0.01),and those in combined therapy decreased even more markedly(P<0.05).Alone in the treatment group ox-LDL antibodies had no significant effect(P>0.05).Combined treatment group can significantly reduce the level of ox-LDL antibody(P<0.01).Conclusions Both atorvastatin alone and atorvastatin combined probucol can decrease the levels of ox-LDL in patients with coronary heart disease,and those in combined therapy decreased even more markedly.Alone in the treatment group ox-LDL antibodies had no significant effect.But combined treatment group can significantly reduce the level of ox-LDL antibody levels.