Aim Observing the effect of pravastatin and folic acid on the carotid atherosclerosis. Methods Dividing 164 cases of acute cerebral infarction patients with carotid atherosclerosis and dyslipidemia randomly into three groups,including pravastatin group,pravastatin and folic acid group,and folic acid group,which have been given medication for 6 months respectively.And then make comparison of the 3 groups before and after treatment about the difference of the serum high sensitivity C-reactive protein(hs-CRP),lipid levels and carotid intima-media thickness(IMT),carotid artery plaque area change. Results By comparison,levels of the serum hs-CRP in the 3 groups decrease significantly(P<0.05),which situation can also be found in the lipid levels and carotid IMT,carotid artery plaque area change(P<0.05).The alteration of lipid levels is statistically significant(P<0.05).In particular,improvement of all the indicators in the pravastatin and folic acid group after treatment,is more obvious than the other two groups(all P<0.05).Conclusions The folic acid combined treatment with pravastatin can reduce serum hs-CRP levels,delay and reverse carotid atherosclerosis better than any single use of pravastatin or folic acid,since the two may have a synergistic effect.Therefore,it is worthy of further exploration in a large-scale,multi-center study.